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:: Volume 9, Issue 33 (9-2018) ::
JPG 2018, 9(33): 35-40 Back to browse issues page
Using fish brain biomarkers to assess the neurotoxicity of aspartame artificial sweetener
Aisan Shirmardani, Aras Rafiee *, Babak Moghadasi
Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran , aras_marine_biology@yahoo.com
Abstract:   (545 Views)
Neurotoxins induce undesirable changes in aquatic organisms. This project assessed the effects of 78.15 g/L aspartame on expression changes of two biomarkers of neurotoxicity (glial fibrillary acidic protein-GFAP and myelin basic protein- MBP) in Cyprinus carpio brain tissue. RNA was extracted from brain tissue. The results of qPCR indicated an increase of 2.5 and 4.2 of MBP and GFAP expression. Elevated levels of these biomarkers suggest the probability of aspartame neurotoxicity. Identifying and monitoring nerve damage using biomarkers can make it easier to diagnose injuries earlier than current methods and provide an opportunity to develop future treatments.
Keywords: Aspartame, Biomarker, Common carp, Neurotoxicity, Gene expression
Full-Text [PDF 198 kb]   (23 Downloads)    
Type of Study: Applied Research | Subject: Marine Biology & Biotechnology
Received: 2021/01/16 | Accepted: 2021/03/25 | ePublished: 2021/05/21
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Shirmardani A, Rafiee A, Moghadasi B. Using fish brain biomarkers to assess the neurotoxicity of aspartame artificial sweetener. JPG. 2018; 9 (33) :35-40
URL: http://jpg.inio.ac.ir/article-1-612-en.html


Volume 9, Issue 33 (9-2018) Back to browse issues page
نشریه علمی پژوهشی خلیج فارس Journal of the Persian Gulf
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